PTH-driven modulation of platelet activity via the NOX2 pathway in postsurgical hypoparathyroidism
HypoPT is associated with heightened platelet reactivity and thrombotic risk. PTH therapy may exacerbate these alterations through a defined molecular mechanism. These findings highlight the need for careful cardiovascular monitoring in HypoPT patients, particularly those receiving PTH analogues.
Authors
- Francesco Piccirillo (ORCID: https://orcid.org/0000-0002-6489-7182)
- Nicola Napoli (ORCID: https://orcid.org/0000-0002-3091-8205)
- Gianmarco Sarto
- Francesco Grigioni (ORCID: https://orcid.org/0000-0002-4767-7073)
- Athanasios D. Anastasilakis (ORCID: https://orcid.org/0000-0002-9624-6296)
- Gaia Tabacco (ORCID: https://orcid.org/0000-0002-6808-0700)
- Sebastiano Sciarretta (ORCID: https://orcid.org/0000-0002-8633-6896)
- Maurizio Forte (ORCID: https://orcid.org/0000-0003-0739-0534)
- Anda Mihaela Naciu (ORCID: https://orcid.org/0000-0002-4576-3381)
- Annunziata Nusca (ORCID: https://orcid.org/0000-0002-5616-3197)
- Federico Bernardini
- Alessandra D’Amico (ORCID: https://orcid.org/0000-0002-5571-4583)
- Michele Mattia Viscusi (ORCID: https://orcid.org/0000-0002-5047-973X)
- Roberto Carnevale (ORCID: https://orcid.org/0000-0002-6216-9595)
- Andrea Palermo
- Ernesto Greco (ORCID: https://orcid.org/0000-0003-3177-5303)
- Valentina Valenti (ORCID: https://orcid.org/0000-0002-6755-9648)
- Luca D’Ambrosio (ORCID: https://orcid.org/0000-0002-8196-8069)
- Cristina Nocella (ORCID: https://orcid.org/0000-0003-4398-6327)
- Giacomo Frati (ORCID: https://orcid.org/0000-0001-5584-6060)
- Beatrice Simeone (ORCID: https://orcid.org/0009-0002-9223-8587)
- Angela Leonardo (ORCID: https://orcid.org/0000-0002-2917-2389)
Institutions
- Foro Italico University of Rome (IT)
- Istituto Neurologico Mediterraneo (IT)
- European University of Rome (IT)
- Maria Cecilia Hospital (IT)
- 424 General Military Hospital (GR)
- Campus Bio Medico University Hospital (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.redox.2025.103896
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00