Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations
This is the first study using a beta cell-specific GAD65/GAD67 knockout model. Endogenous beta cell-derived GABA is critical for modulating insulin secretion by maintaining proper Ca<sup>2+</sup> oscillation dynamics. GABA signaling likely operates as a delayed negative feedback mechanism that reinforces oscillatory homeostasis in islets. The loss of GABA responsiveness, as seen in metabolic stress or T2D, may contribute to islet dysfunction. This work establishes GABA as a key regulator of islet rhythm and glucose responsiveness.
Authors
- Dylan Smurlick (ORCID: https://orcid.org/0000-0003-4551-8885)
- DAVID W. HAGAN
- Sandra M. Ferreira (ORCID: https://orcid.org/0000-0002-1002-3973)
- Marjan Slak Rupnik (ORCID: https://orcid.org/0000-0002-3744-4882)
- Edward A. Phelps (ORCID: https://orcid.org/0000-0001-8666-805X)
- Alexandra E. Cuaycal (ORCID: https://orcid.org/0000-0002-9060-6326)
- Chad Rancourt
- Austin E. Stis
- Adrienne E. Widener (ORCID: https://orcid.org/0009-0008-7401-3441)
- Martha Campbell‐Thompson (ORCID: https://orcid.org/0000-0001-6878-1235)
- Dongtao Fu
- Arabella G Readey
Institutions
- University of Florida (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.molmet.2025.102268
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01