Grandmaternal exercise improves the metabolic health of second-generation offspring generated from F1 females
Voluntary wheel running exercise in female mice during pregnancy leads to metabolic improvements in her grand offspring, despite no direct intervention of the intermediate maternal generation. Maternal physical activity during pregnancy may reduce metabolic diseases in later generations.
Authors
- Pasquale Nigro (ORCID: https://orcid.org/0000-0002-2918-8356)
- Michael F. Hirshman (ORCID: https://orcid.org/0000-0001-8728-6379)
- Laurie J. Goodyear (ORCID: https://orcid.org/0000-0002-6299-2928)
- Fahmida Jahan
- Joji Kusuyama (ORCID: https://orcid.org/0000-0003-4054-1939)
- Ana Bárbara Alves-Wagner
Institutions
- Joslin Diabetes Center (US)
- Harvard University (US)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jshs.2025.101096
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99