Slowing down to take it in: Endocytosis during cellular aging
Aging cells functionally decline and accumulate damage through poorly understood mechanisms. In this issue, Antentor et al. (https://doi.org/10.1083/jcb.202412064) find that increased vacuolar pH in older yeast cells slows clathrin-mediated endocytosis. These findings have broad implications in aging-related plasma membrane protein quality control.
Authors
- Derek C. Prosser (ORCID: https://orcid.org/0000-0002-6738-2758)
Institutions
- Virginia Commonwealth University (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1083/jcb.202510010
- Citations
- 1
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Science Foundation
- University of Pittsburgh