LncRNA and mRNA expression characteristic and bioinformatic analysis in anemic diabetic foot ulcers

Our analysis of anemia in DFU identifies distinct lncRNA-mRNA co-expression networks linked to hemoglobin deficiency. Key lncRNAs correlate strongly with mRNAs involved in perturbed iron handling and sustained inflammation. This suggests that dysregulation within these networks significantly contributes to the pathology of DFU with concurrent anemia, highlighting potential regulatory roles for these lncRNAs and offering avenues for diagnostic development.