Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects

Psychomotor speed, but not executive function, was sensitive to changes in systemic inflammation in a gender-specific way. -Gender-specific differences in neurological aging remain a fruitful direction and critical target for future intervention research aimed at addressing preclinical Alzheimer's disease and accelerated aging.

Authors

Patrick J. Smith (ORCID: https://orcid.org/0000-0002-6374-0298)
Suzanne C. Segerstrom (ORCID: https://orcid.org/0000-0002-4020-111X)
Elana M. Gloger (ORCID: https://orcid.org/0000-0001-7099-2007)

Institutions

University of North Carolina at Chapel Hill (US)
Pennsylvania State University (US)
Oregon State University (US)
University of Kentucky (US)

Publication Details

Journal: The Journals of Gerontology Series B
Published: 2025-10-07
DOI: https://doi.org/10.1093/geronb/gbaf106
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects

Patrick J. Smith, Suzanne C. Segerstrom, Elana M. Gloger

Oct 7, 2025

The Journals of Gerontology Series B

Neuroinflammation and Neurodegeneration Mechanisms

article

Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects

Patrick J. Smith, Suzanne C. Segerstrom, Elana M. Gloger

October 7, 2025article en

Abstract

Psychomotor speed, but not executive function, was sensitive to changes in systemic inflammation in a gender-specific way. -Gender-specific differences in neurological aging remain a fruitful direction and critical target for future intervention research aimed at addressing preclinical Alzheimer's disease and accelerated aging.

The Journals of Gerontology Series BVol. 80(11)

University of North Carolina at Chapel Hill (US), Pennsylvania State University (US), Oregon State University (US), University of Kentucky (US)

Openalex Percentile: Top 64%

Neuroinflammation and Neurodegeneration Mechanisms

DOI Source OpenAlex

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Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects — Patrick J. Smith, Suzanne C. Segerstrom, et al. · The Journals of Gerontology Series B (2025) | TGRS Research Map | TGRS