Association of Statistical Methodology and Design in Preclinical Animal Studies With Successful Translation Into Clinical Phase 2 Trials
Statistical practice in animal studies was generally poor or not well reported, with rates of some statistical mistakes occurring more frequently before negative trials than positive trials. This was an exploratory study with a highly selected sample, yet it suggests that translational decision making should include evaluation of the quality of preclinical statistical practice.
Authors
- Olivia Hogue (ORCID: https://orcid.org/0000-0002-3985-3831)
- Felicia L. Pasadyn
- Mary A. Dolansky (ORCID: https://orcid.org/0000-0002-6472-1275)
- Claire Sonneborn (ORCID: https://orcid.org/0000-0003-3038-5418)
- Jill S. Barnholtz‐Sloan (ORCID: https://orcid.org/0000-0001-6190-9304)
- Kenneth B. Baker (ORCID: https://orcid.org/0000-0002-4435-7015)
- Nancy A. Obuchowski (ORCID: https://orcid.org/0000-0003-1891-7477)
- Sanjana Tumma
- Emily Smith (ORCID: https://orcid.org/0000-0002-1916-0843)
- Megan Zelinsky
- Isabella Genuario
- Marissa Salvaterra
- Thwisha Anantasagar
- Tanvi Prabhakar
- Jumoke Adebulu
Institutions
- Cleveland Clinic (US)
- Harvard University Press (US)
- Quantitative BioSciences (US)
- National Cancer Institute (US)
- The Neurological Institute (US)
- Division of Cancer Epidemiology and Genetics
- Case Western Reserve University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214250
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 2.63