Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced retinal pigment epithelium degeneration in mice
Ferroptosis plays a critical role in RPE damage by atRAL. Inhibition of ferroptosis by Fer-1 may enhance RPE cell survival and prevent subsequent photoreceptor degeneration in STGD1 and dAMD.
Authors
- Yalin Wu (ORCID: https://orcid.org/0000-0001-5906-5675)
- Baoting He (ORCID: https://orcid.org/0000-0002-9976-7775)
- Yuling Chen (ORCID: https://orcid.org/0000-0002-8399-2070)
- Xiao‐Qing Shen
- Jingmeng Chen
- Ruitong Xi
Institutions
- Shenzhen University (CN)
- Xiamen University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12967-025-07195-7
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Xiamen University