Integrating urinary dual-gene methylation and VI-RADS score to predict residual tumors after TURBT in NMIBC: a nomogram-based model
Urinary H4C6 and TWIST1 gene methylation, along with VI-RADS scoring, show high diagnostic performance in predicting residual tumors following TURBT in NMIBC patients. A combined prediction model incorporating dual-gene methylation, hematuria, and VI-RADS scores achieves superior discrimination, excellent calibration, and strong clinical utility.
Authors
- Linfeng Li (ORCID: https://orcid.org/0000-0001-6185-4999)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-6227-024X)
- Bin Cao (ORCID: https://orcid.org/0000-0001-6991-0350)
- Qi Wang (ORCID: https://orcid.org/0000-0001-6243-1402)
- Lin Qisheng
- Wei Weiyang
- Huang Yaqiang
Institutions
- Zhongshan People's Hospital (CN)
Publication Details
- Journal
- BMC Urology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12894-025-01857-w
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00