UK real-world data of radium-223 dichloride in metastatic prostate cancer
The National Radium-223 Dichloride Audit was the first and largest multicentre prospective analysis of treatment patterns, outcomes, and quality of life data in patients treated with radium-223 in the UK. Radium-223 can be administered safely to patients previously treated with other life-prolonging therapies. Efficacy and safety data compare favourably with clinical trial and other real-world data. Our results suggest that its use earlier in the treatment pathway is associated with longer survival.
Authors
- Duncan B. McLaren (ORCID: https://orcid.org/0000-0002-9862-4158)
- Neil McPhail (ORCID: https://orcid.org/0000-0002-1847-7953)
- Angus Robinson (ORCID: https://orcid.org/0000-0002-5961-2189)
- Gail Buchanan
- John McGrane (ORCID: https://orcid.org/0000-0001-9371-3250)
- David Bottomley (ORCID: https://orcid.org/0000-0003-3948-5490)
- Robert J. Jones (ORCID: https://orcid.org/0000-0002-2904-6980)
- Joe M. O’Sullivan (ORCID: https://orcid.org/0000-0001-6999-2739)
- G. M. RACE
- Loretta Sweeney
- Amarnath Challapalli (ORCID: https://orcid.org/0000-0002-3683-9583)
- Santhanam Sundar (ORCID: https://orcid.org/0000-0003-0850-5161)
- Vincent Khoo (ORCID: https://orcid.org/0000-0002-0763-6832)
- Xue Jiang (ORCID: https://orcid.org/0000-0002-2518-3355)
- Irene Stratton (ORCID: https://orcid.org/0000-0003-1172-7865)
- Robert B. Stevenson (ORCID: https://orcid.org/0000-0002-7985-5487)
- John Logue (ORCID: https://orcid.org/0000-0002-5900-0676)
- Manreet Randhawa
- Danish Mazhar
Institutions
- Queen's University Belfast (GB)
- University of Cambridge (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Royal Cornwall Hospital (GB)
- Western General Hospital (GB)
- Royal Sussex County Hospital (GB)
- Beatson West of Scotland Cancer Centre (GB)
- Raigmore Hospital (GB)
- Freeman Hospital (GB)
- Nottingham City Hospital (GB)
- Bridge University (SS)
- NIHR Bristol Biomedical Research Centre (GB)
- Royal Marsden Hospital (GB)
- The Christie NHS Foundation Trust (GB)
- Velindre Cancer Centre (GB)
- University of Southampton (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Nuclear Medicine Communications
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1097/mnm.0000000000002050
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00