Plasma folate dynamics in Plasmodium falciparum-infected African children treated with artemisinin combination therapy and single low-dose primaquine or placebo
SLDPQ and G6PD status did not compromise posttreatment plasma folate concentrations in young children with acute uncomplicated falciparum malaria, providing additional evidence of SLDPQ safety and supporting its use without G6PD testing. Trial registration The trial is registered, reference number ISRCTN11594437.
Authors
- Peter Olupot‐Olupot (ORCID: https://orcid.org/0000-0002-5757-609X)
- Thomas N. Williams (ORCID: https://orcid.org/0000-0003-4456-2382)
- Caterina Fanello (ORCID: https://orcid.org/0000-0003-1932-9562)
- Nicholas Day (ORCID: https://orcid.org/0000-0003-2309-1171)
- Kathryn Maitland (ORCID: https://orcid.org/0000-0002-0007-0645)
- Walter Taylor (ORCID: https://orcid.org/0000-0001-6236-0464)
- Chiraporn Taya
- Marie A. Onyamboko (ORCID: https://orcid.org/0000-0002-7501-5931)
- Sophie Uyoga (ORCID: https://orcid.org/0000-0003-1746-7873)
- Natenapa Chimjinda
- Mavuto Mukaka
- Solomon Damilare Ajayi
- Dhol S Ayuen
Institutions
- Mahidol University (TH)
- Angkor Hospital for Children (KH)
- Mbale Hospital (UG)
- Kenya Medical Research Institute (KE)
- Busitema University (UG)
- University of Kinshasa (CD)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Imperial College London (GB)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12936-025-05567-4
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Government of the United Kingdom
- National Institute for Health and Care Research
- Department for International Development, UK Government
- Department for International Development
- Medical Research Council