A pragmatic, randomised, open-label, multi-centre UK registry-facilitated trial evaluating the effect of high-dose cholecalciferol on mortality in patients on dialysis: the SIMPLIFIED trial
EudraCT Number: 2015-005003-88; ISRCTN Number: 15087616 (registration date 30th December 2015) ( https://doi.org/10.1186/ISRCTN15087616 ). Recruitment commenced in March 2017.
Authors
- Ming Cui (ORCID: https://orcid.org/0000-0002-1173-0645)
- Ian B. Wilkinson (ORCID: https://orcid.org/0000-0001-6598-9399)
- Thomas F. Hiemstra
- David C. Wheeler (ORCID: https://orcid.org/0000-0001-8121-5182)
- Adam P. Wagner (ORCID: https://orcid.org/0000-0002-9101-3477)
- Simon Bond (ORCID: https://orcid.org/0000-0003-2528-1040)
- Toby J L Humphrey (ORCID: https://orcid.org/0000-0002-1084-3701)
- Rona Smith (ORCID: https://orcid.org/0000-0002-7438-5156)
- Fergus John Caskey (ORCID: https://orcid.org/0000-0002-5199-3925)
- Ed Wilson (ORCID: https://orcid.org/0000-0002-8369-1577)
- Francis Dowling
- Barbara Vencilas
Institutions
- University of East Anglia (GB)
- University of Exeter (GB)
- University of Cambridge (GB)
- Kidney Research UK (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- University of Bristol (GB)
- University College London (GB)
Publication Details
- Journal
- Trials
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s13063-025-09134-9
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Cambridge
- Cambridge University Hospitals
- NIHR Cambridge Biomedical Research Centre
- Fogarty International Center