Investigating the simultaneous effect of longitudinal biomarkers on long-term kidney transplant failure in Iranian kidney transplant patients: a multivariate joint model
The results of this study underscore the importance of multivariate joint modeling for investigating the simultaneous effects of longitudinal biomarkers on the risk of kidney graft failure. This model revealed a simultaneous association between three longitudinal biomarkers-serum creatinine, BUN, and hematocrit-and the risk of graft failure in the study's population. Regular monitoring of these biomarkers may help identify patients at higher risk of graft failure, enabling closer clinical follow-up and timely intervention to preserve graft function.
Authors
- Rasoul Alimi (ORCID: https://orcid.org/0000-0001-7780-6326)
- Niloofar Shabani
- Mehdi Yaseri (ORCID: https://orcid.org/0000-0002-4066-873X)
- Hojjat Zeraati (ORCID: https://orcid.org/0000-0002-8635-4322)
- Fatemeh Nazemian (ORCID: https://orcid.org/0000-0003-2257-661X)
Institutions
- Mashhad University of Medical Sciences (IR)
- Torbat Heydarieh University of Medical Sciences (IR)
- Imam Reza Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12882-025-04498-1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tehran University of Medical Sciences and Health Services