From Incision to Immunity: Integrating Surgery and Immunotherapy in Non-Small Cell Lung Cancer
Lung cancer is the most common cause of death due to cancer in the world, and non-small cell lung cancer (NSCLC) is the most common form of lung cancer, representing approximately 84% of all cases. Due to its frequency and mortality, the amount of research on this subject has been greatly increased and new techniques to improve health outcomes have been established. While surgery remains the gold standard of treatment, immunotherapy used alone or in conjunction with surgery shows promising results. This review aims to give an overview of current and new surgical and immunotherapy methods used for the treatment of NSCLC, as well as ways in which they can be combined and the clinical outcomes for patients with each treatment modality. Additionally, it will seek to highlight any gaps in current knowledge of treatment and propose further studies to improve the efficacy of NSCLC treatments.
Authors
- Mark R. Wakefield (ORCID: https://orcid.org/0000-0003-2598-7895)
- Yujiang Fang (ORCID: https://orcid.org/0000-0002-9107-7374)
- Michael Ann Janes
- Aidan A. Schmidt
- Ashvin Chouhan (ORCID: https://orcid.org/0009-0006-2052-7362)
- Garret A. Krieg
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
- University of Missouri (US)
- Des Moines University (US)
Publication Details
- Journal
- Immuno
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3390/immuno5040048
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institute of Engineering Research, Seoul National University