Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Oncologic Patients—A New Promise? Preliminary Results
This is the first clinical evaluation of a topical combination with new concentrations of amitriptyline and ketamine for CIPN. The results suggest this formulation offers a safe and effective option for symptomatic relief. Larger randomized controlled trials and exploration of transdermal delivery systems are warranted to validate these findings and optimize treatment outcomes.
Authors
- Moshe Schaffer (ORCID: https://orcid.org/0000-0003-1294-4116)
- Tatiana Charkovsky
- Noam Asna (ORCID: https://orcid.org/0009-0007-1720-069X)
- Murad Asali (ORCID: https://orcid.org/0000-0003-2275-6805)
- Sharon Pelles
- Ron Batash
- Syed Ahsan Ali (ORCID: https://orcid.org/0000-0002-8174-8824)
Institutions
- Ben-Gurion University of the Negev (IL)
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Wolfson Medical Center (IL)
- Shaare Zedek Medical Center (IL)
- Barzilai Medical Center (IL)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3390/cancers17203321
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05