T1D-Related Cataract Risk Amplification: Mendelian Randomisation Confirms a Dual Hit of Immune-Inflammatory Burden and Metabolic Stress
T1D causally increases the risk of cataract through the disruption of immuneinflammatory and metabolic pathways. Targeting immune-metabolic interactions may offer novel therapeutic strategies for preventing diabetic cataracts.
Authors
- Jiancen Tang
- Kunling Guo
- Wei Du (ORCID: https://orcid.org/0000-0001-8705-1983)
- Wei Lou
- Qian Li (ORCID: https://orcid.org/0000-0003-0359-5604)
- Rui Li (ORCID: https://orcid.org/0000-0002-0341-5645)
- Mengyu Wang (ORCID: https://orcid.org/0000-0001-9564-8624)
- Hongping Cui
- Xue Wang (ORCID: https://orcid.org/0009-0006-7955-4410)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai East Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-10-09
- DOI
- https://doi.org/10.2174/0113862073425549250926170012
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00