Chemotherapy in adult patients with pilocytic astrocytoma: a retrospective multicenter cohort study
Chemotherapy offers meaningful disease control in adolescents and young adults with irresectable symptomatic pilocytic astrocytoma, after prior treatments. However, with the improved efficacy and tolerability of targeted treatments, such as BRAF/MEK inhibitors, treatment is shifting away from traditional chemotherapy and radiotherapy. Nevertheless, chemotherapy may still represent a viable treatment option in adolescent and young adults when no actionable molecular targets are identified or when targeted therapies have failed.
Authors
- Johan A F Koekkoek (ORCID: https://orcid.org/0000-0002-3648-9616)
- Anja Gijtenbeek
- Martin J. van den Bent (ORCID: https://orcid.org/0000-0001-5710-5127)
- Jacoline E. C. Bromberg (ORCID: https://orcid.org/0000-0002-3830-7142)
- Walter Taal (ORCID: https://orcid.org/0000-0002-5530-7259)
- Nathalie E. Synhaeve
- Filip De Vos (ORCID: https://orcid.org/0000-0002-9082-5991)
- Mathilde C.M. Kouwenhoven (ORCID: https://orcid.org/0000-0001-5252-4365)
- Martinus P G Broen (ORCID: https://orcid.org/0000-0002-8834-2202)
- Marion Smits (ORCID: https://orcid.org/0000-0001-5563-2871)
- Lisa Berg (ORCID: https://orcid.org/0000-0002-8707-180X)
- Antoinette Y. N. Schouten‐van Meeteren (ORCID: https://orcid.org/0000-0002-1089-8091)
- Joyce Wilbers
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Medisch Centrum Haaglanden (NL)
- Amsterdam Neuroscience (NL)
- Princess Máxima Center (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s11060-025-05275-8
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63