Comparing the Influence of Heterogeneity on Model Outcomes in Individual-Level and Cohort Simulations: An Exploratory Simulation Study
Patient heterogeneity can affect the outcomes of individual and cohort simulations differently, but reflecting more heterogeneity does not necessarily increase differences in simulation outcomes. However, age-dependent mortality affected analytic outcomes differently, suggesting a need for caution when developing cohort models if age is heterogeneous.
Authors
- Tim M. Govers (ORCID: https://orcid.org/0000-0002-4877-3198)
- Hendrik Koffijberg (ORCID: https://orcid.org/0000-0002-1753-0652)
- Evelien B. van Well (ORCID: https://orcid.org/0000-0002-6030-3615)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- University of Twente (NL)
Publication Details
- Journal
- PharmacoEconomics
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s40273-025-01547-3
- Citations
- 1
- Primary Topic
- demographic modeling and climate adaptation
- Type
- article
- Field-Weighted Citation Impact
- 2.11
Funders
- Radboud Universitair Medisch Centrum