Correlation of Homocysteine and Biochemical Markers in Pregnancy Loss: A Molecular‐Level Study

ABSTRACT Homocysteine, a sulfur‐containing amino acid derived from methionine metabolism, plays a pivotal role in methylation and transsulfuration pathways. Dysregulation in these pathways can lead to hyperhomocysteinemia, which has been implicated in various pathological conditions, including adverse pregnancy outcomes. This study investigates the levels of homocysteine and its relationship with selected biochemical markers—interleukin‐6 (IL‐6), triiodothyronine (T3), thyroxine (T4), and thyroid‐stimulating hormone (TSH)—in women who have experienced miscarriage. A total of 90 women, aged 18–42 years, were enrolled and categorized into two groups: 60 women with a history of miscarriage and 30 healthy, non‐pregnant controls. Biochemical assessments revealed significantly elevated homocysteine and IL‐6 levels in the miscarriage group, accompanied by altered thyroid hormone profiles. These findings highlight a potential molecular interplay between elevated homocysteine, inflammatory responses, and hormonal imbalance in the etiology of miscarriage. This study underscores the importance of biochemical profiling as a diagnostic and prognostic tool in reproductive health.