Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period
Findings provide additional evidence for the role of IL-6 and TNF-α in perinatal depressive symptoms. Anhedonia symptoms and third-trimester inflammation may be particularly important. Future work focusing on dimensions of depressive symptoms and inflammatory processes across the perinatal period is key to elucidating specific temporal associations. Further investigation of how changes in inflammation across pregnancy relate to specific types of depressive symptoms could inform and improve perinatal care and intervention.
Authors
- Barbara Warner (ORCID: https://orcid.org/0000-0002-9910-4461)
- Mary Kimmel (ORCID: https://orcid.org/0000-0002-6270-5394)
- J. Philip Miller (ORCID: https://orcid.org/0000-0003-4568-6846)
- Cynthia Rogers (ORCID: https://orcid.org/0000-0001-6251-8436)
- Joan L. Luby (ORCID: https://orcid.org/0000-0001-5352-1721)
- Gregory E. Miller (ORCID: https://orcid.org/0000-0002-7217-1082)
- Deanna M. Barch (ORCID: https://orcid.org/0000-0003-1693-8506)
- Tara A. Smyser (ORCID: https://orcid.org/0000-0003-2977-8214)
- Christopher D. Smyser (ORCID: https://orcid.org/0000-0002-4716-5190)
- Edith Chen
- Margaret M Redic
Institutions
- Northwestern University (US)
- Washington University in St. Louis (US)
- Hologic (Germany) (DE)
Publication Details
- Journal
- Psychoneuroendocrinology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.psyneuen.2025.107648
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00