Diosgenin ameliorates CLP-induced sepsis in mice via suppressing inflammatory responses and preserving intestinal mucosal barrier integrity
Diosgenin improved survival, suppressed inflammatory responses, and preserving intestinal mucosal barrier integrity in CLP-induced septic mice. These protective effects might involve alterations in mCRAMP expression and TLR4/MyD88 signaling.
Authors
- Jiajun Ling (ORCID: https://orcid.org/0000-0002-1384-761X)
- Jiajia Zeng (ORCID: https://orcid.org/0000-0002-5376-7059)
- Xiaoqi Huang (ORCID: https://orcid.org/0000-0003-3401-5000)
- Rong-Feng Lin
- Xianfei Wang (ORCID: https://orcid.org/0000-0003-3669-6866)
- Qiting Huang (ORCID: https://orcid.org/0000-0002-3975-4526)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-0852-8558)
- Xiaoxiong Zhong (ORCID: https://orcid.org/0000-0001-9307-6247)
- Huamin Wang (ORCID: https://orcid.org/0000-0002-8153-2337)
- Shuya Sun
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangdong Pharmaceutical University (CN)
- Guangzhou University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Province Women and Children Hospital (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.molimm.2025.10.005
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00