A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5–DUSP1 axis for mitochondrial repair
LIG-Na ameliorated DOX-mediated cardiac dysfunction and MQH dysregulation through the SIRT5/DUSP1-PHB2S91 phosphorylation axis, thereby effectively suppressing mitochondrial dysfunction and mitigating DIC in mice.
Authors
- Hongshuo Shi (ORCID: https://orcid.org/0000-0003-0012-5869)
- Boxian Pang (ORCID: https://orcid.org/0000-0002-3400-6879)
- Xing Chang
- Guobin Liu (ORCID: https://orcid.org/0000-0003-1074-0857)
- You Yang (ORCID: https://orcid.org/0000-0002-5695-1046)
- Zhijiang Guo (ORCID: https://orcid.org/0009-0003-5653-8440)
- Fenglei Zhang (ORCID: https://orcid.org/0000-0002-3217-9039)
- Man Zheng (ORCID: https://orcid.org/0009-0002-7437-0525)
- Jianxiao Liang
- Yifeng Nie
- Wenshi Xu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shandong Provincial Hospital (CN)
- National Center for Nanoscience and Technology (CN)
- Guang’anmen Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s12951-025-03667-6
- Citations
- 11
- Primary Topic
- Electron Spin Resonance Studies
- Type
- article
- Field-Weighted Citation Impact
- 17.97