Endothelial PIEZO1 activation impairs osteogenesis via GREM1-mediated inhibition of BMP signaling
Our study reveals a dual role of PIEZO1 in bone biology, demonstrating that its activation disrupts vascular-osteogenic coupling and suppresses osteoblast differentiation through the PIEZO1-GREM1-BMP4 axis. These findings suggest that caution should be taken when targeting PIEZO1 for bone regeneration and highlight the importance of dose and duration in therapeutic applications.
Authors
- Jing He (ORCID: https://orcid.org/0000-0003-1785-2800)
- Haoran Zhang (ORCID: https://orcid.org/0000-0001-9513-5378)
- Bowen Wang (ORCID: https://orcid.org/0000-0002-4583-2287)
- Jianyu Liu (ORCID: https://orcid.org/0000-0003-0714-1319)
- Ying Xing (ORCID: https://orcid.org/0000-0003-3584-7466)
- Shengyi Zhou
- Juan Song (ORCID: https://orcid.org/0000-0002-6612-428X)
- Feng Guo (ORCID: https://orcid.org/0000-0003-0565-9317)
- Xiangyu Zeng (ORCID: https://orcid.org/0000-0002-3640-0052)
- Ziwen Liu (ORCID: https://orcid.org/0000-0003-3894-1677)
Institutions
- Harbin Medical University (CN)
- Chinese Academy of Sciences (CN)
- 117th Hospital of People's Liberation Army (CN)
- Shanghai Institute of Organic Chemistry (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Shanghai Sixth People's Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cell Calcium
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.ceca.2025.103084
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00