High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms
HFD mitigates age-related auditory and vestibular impairments by utilizing macrophage-driven anti-inflammatory processes, potentially through polarization towards an M2 phenotype. This research offers fresh perspectives for creating specific treatments, indicating the variable therapeutic possibilities of dietary adjustments in age-related cellular damage. However, the potential metabolic consequences of HFD warrant careful consideration.
Authors
- J.W. Zhang
- Ting Yang (ORCID: https://orcid.org/0000-0002-7027-5179)
- Jiang Xu (ORCID: https://orcid.org/0000-0003-0369-4848)
- Jing Ke (ORCID: https://orcid.org/0000-0003-1254-4323)
- Yiting Liu (ORCID: https://orcid.org/0000-0003-2362-8530)
- Wei Yuan (ORCID: https://orcid.org/0000-0001-9171-0267)
Institutions
- Chongqing Emergency Medical Center (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.exger.2025.112930
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00