Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induced colitis-associated cancer mouse model
These findings provide a foundation for further investigation of cathelicidin derivatives in colorectal cancer therapy.
Authors
- Elżbieta Kamysz (ORCID: https://orcid.org/0000-0002-9741-4562)
- Jakub Włodarczyk (ORCID: https://orcid.org/0000-0003-2010-5136)
- Jakub Fichna (ORCID: https://orcid.org/0000-0002-8443-4417)
Institutions
- Medical University of Silesia (PL)
- University of Gdańsk (PL)
- Medical University of Lodz (PL)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s43440-025-00790-x
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00