Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia
These results emphasize the regional and time-dependent regulation of gene expression in the hippocampus after I/R. The identified up- and downregulated genes represent novel molecular targets whose pharmacological modulation could enhance endogenous neuroprotective pathways, revealing new therapeutic avenues for stroke.
Authors
- Anna Boratyńska-Jasińska (ORCID: https://orcid.org/0000-0003-1337-3175)
- Barbara Zabłocka (ORCID: https://orcid.org/0000-0003-3116-7295)
- M Beresewicz (ORCID: https://orcid.org/0000-0002-2204-5184)
- Łukasz Charzewski (ORCID: https://orcid.org/0000-0002-4667-1390)
- Anita Lewczuk
Institutions
- Logifact (Poland) (PL)
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1007/s43440-025-00792-9
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81