A Challenging Case of Secondary Hyperparathyroidism From Hypovitaminosis D in a Young Man With Hypertensive Crisis and Target Organ Damage

Hypertension is a common global condition, with most cases being primary and a minority arising from secondary causes, often endocrine in origin. Young patients presenting with hypertensive crises are more likely to have secondary aetiologies, necessitating a systematic and comprehensive workup. This case report describes a 37-year-old man presenting with severe headache, visual disturbances, and chest pain, with a blood pressure of 250/170 mmHg. Evaluation revealed advanced retinopathy, cerebral microhaemorrhages, renal impairment, and left ventricular hypertrophy, consistent with target organ damage. Further investigations identified secondary hyperparathyroidism due to profound hypovitaminosis D as the likely cause. Targeted treatment corrected the vitamin D deficiency and hypocalcaemia while gradually controlling blood pressure, leading to a favourable outcome. This exceptionally rare presentation underscores the need for wide-ranging diagnostic assessment in young patients with hypertensive crises, as identifying reversible secondary causes can significantly influence prognosis and long-term morbidity.

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Publication Details

Journal
Cureus
Published
2025-10-14
DOI
https://doi.org/10.7759/cureus.94596
Primary Topic
Parathyroid Disorders and Treatments
Type
article
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0.00
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article

A Challenging Case of Secondary Hyperparathyroidism From Hypovitaminosis D in a Young Man With Hypertensive Crisis and Target Organ Damage

Abdelrahim Elmejrab, Zain Al Abdeen Al Zuabi
Cureus
Parathyroid Disorders and Treatments
article

A Challenging Case of Secondary Hyperparathyroidism From Hypovitaminosis D in a Young Man With Hypertensive Crisis and Target Organ Damage

Abdelrahim Elmejrab, Zain Al Abdeen Al Zuabi
article en

Abstract

Hypertension is a common global condition, with most cases being primary and a minority arising from secondary causes, often endocrine in origin. Young patients presenting with hypertensive crises are more likely to have secondary aetiologies, necessitating a systematic and comprehensive workup. This case report describes a 37-year-old man presenting with severe headache, visual disturbances, and chest pain, with a blood pressure of 250/170 mmHg. Evaluation revealed advanced retinopathy, cerebral microhaemorrhages, renal impairment, and left ventricular hypertrophy, consistent with target organ damage. Further investigations identified secondary hyperparathyroidism due to profound hypovitaminosis D as the likely cause. Targeted treatment corrected the vitamin D deficiency and hypocalcaemia while gradually controlling blood pressure, leading to a favourable outcome. This exceptionally rare presentation underscores the need for wide-ranging diagnostic assessment in young patients with hypertensive crises, as identifying reversible secondary causes can significantly influence prognosis and long-term morbidity.

CureusVol. 17(10)
Queen Elizabeth Hospital King's Lynn NHS Foundation Trust (GB)
Openalex Percentile: Top 70%
Parathyroid Disorders and Treatments
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