Genomic Transformers: Innovative Approaches to Hepatitis Virus Subtyping

This article introduces a highly effective method for the classification of four subtypes of Hepatitis virus B, C, D, and E utilizing the sophisticated Transformer models. Initially, the DNA sequences are segmented into discrete non overlapping kmers, which effectively transforms the genetic information into a structured vocabulary. Subsequently, these segmented words are converted into vectorized representations through the innovative application of the Word2Vec technique. These detailed, highdimensional vectors capture the nuanced patterns within the sequences, which are then processed by powerful Transformer models for precise classification which results in classification accuracy of 99.49%. This advanced approach leverages the cutting-edge capabilities of Natural Language Processing to provide deep insights into the genetic basis of different Hepatitis virus' subtypes, marking a leap forward in bio-informatics.

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Publication Details

Published
2025-02-27
DOI
https://doi.org/10.1109/icbcb64873.2025.11198033
Primary Topic
Hepatitis C virus research
Type
article
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article

Genomic Transformers: Innovative Approaches to Hepatitis Virus Subtyping

Majid Ahmadi, Q. M. Jonathan Wu, Vatsal Shah, Mohammad Hassanzadeh et al.
Hepatitis C virus research
article

Genomic Transformers: Innovative Approaches to Hepatitis Virus Subtyping

Majid Ahmadi, Q. M. Jonathan Wu, Vatsal Shah, Mohammad Hassanzadeh, Love Fadia
article en

Abstract

This article introduces a highly effective method for the classification of four subtypes of Hepatitis virus B, C, D, and E utilizing the sophisticated Transformer models. Initially, the DNA sequences are segmented into discrete non overlapping kmers, which effectively transforms the genetic information into a structured vocabulary. Subsequently, these segmented words are converted into vectorized representations through the innovative application of the Word2Vec technique. These detailed, highdimensional vectors capture the nuanced patterns within the sequences, which are then processed by powerful Transformer models for precise classification which results in classification accuracy of 99.49%. This advanced approach leverages the cutting-edge capabilities of Natural Language Processing to provide deep insights into the genetic basis of different Hepatitis virus' subtypes, marking a leap forward in bio-informatics.

University of Windsor (CA)
Openalex Percentile: Top 61%
Hepatitis C virus research
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Genomic Transformers: Innovative Approaches to Hepatitis Virus Subtyping — Majid Ahmadi, Q. M. Jonathan Wu, et al. · (2025) | TGRS Research Map | TGRS