Design and Numerical Analysis of a Temperature-Tuned Platinum Diselenide SPR Biosensor for Human Adipose Tissue Detection

In this study, a surface plasmon resonance (SPR) biosensor utilizing platinum diselenide (PtSe2) and silver (Ag) for biosensing protocols is designed and simulated for the detection of human adipose tissues (HAT). Beyond the other members of the 2D material family, PtSe2 remarkable optoelectronic capabilities have garnered significant interest in newly produced two-dimensional (2D) materials. PtSe2 is a similar structure to graphene and phosphorene. We have used the transfer matrix method to study the SPR sensors through PtSe2. The predicted PtSe2 biochemical sensors can detect analytic signals, according to the simulation results. The SPR biosensor demonstrates a maximum sensitivity of 3098 nm/RIU, suggesting its ability to detect minute refractive index changes with remarkable precision. Furthermore, a figure of merit of 34.95 <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RIU</i><sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> demonstrates the biosensor's capacity to detect tiny fluctuations in target analyte concentration. Additionally, the remarkably low limit of detection (LoD) of 7.3245× 10<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−4</sup> ensures early and accurate detection.