Bupi Yishen formula against chronic kidney injury via Akkermansia muciniphila mediated group 3 innate lymphoid cells activation to repair intestinal barrier funciton
BYF may enhance intestinal barrier function by upregulating Akkermansia muciniphila and the ILC3s-IL-22 axis, thereby reducing toxin translocation, suppressing inflammation, alleviating renal fibrosis, and slowing CKD progression. These effects may involve activation of Akkermansia muciniphila-mediated retinoic acid synthesis, which modulates ILC3s-IL-22 signalling in mice with CKD. The breakthrough in our study lies in demonstrating that BYF, through its regulation of gut microbiota and immune cells, significantly impacts the gut-kidney axis to alleviate CKD progression.
Authors
- Zhaoyu Lu (ORCID: https://orcid.org/0000-0002-8989-6127)
- Yenan Mo (ORCID: https://orcid.org/0000-0002-4926-2904)
- Zhang La (ORCID: https://orcid.org/0000-0002-8300-2890)
- Yuchi Wu (ORCID: https://orcid.org/0000-0003-4974-0758)
- Yuanyuan Zhang (ORCID: https://orcid.org/0009-0008-4199-3906)
- Wenbo Liu (ORCID: https://orcid.org/0000-0003-3627-3337)
- Xusheng Liu (ORCID: https://orcid.org/0000-0002-0931-4925)
- Lihua Huang (ORCID: https://orcid.org/0000-0002-8943-8038)
- Shanqiang Gu (ORCID: https://orcid.org/0000-0002-9292-9129)
- Yimei Cai
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1016/j.phymed.2025.157412
- Citations
- 2
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 4.01