Transcriptomic profiling in <i>Mycobacterium avium</i> complex pulmonary disease identifies clusters linked to disease severity and neutrophil activation
Gene expression profiling in MAC pulmonary disease patients identified three distinct clusters, with the most severe cluster characterized by neutrophil activation. Six genes were associated with disease severity and prognosis, though their causal roles require further investigation.
Authors
- Kodai Ueda (ORCID: https://orcid.org/0000-0002-9023-9458)
- Takefumi Saito
- Yuko Morishima (ORCID: https://orcid.org/0000-0002-7407-4243)
- Chio Sakai
- Masafumi Muratani (ORCID: https://orcid.org/0000-0002-0276-8000)
- Yukio Ishii (ORCID: https://orcid.org/0000-0002-3475-181X)
- Masayuki Nakajima (ORCID: https://orcid.org/0000-0002-5866-5588)
- Sosuke Matsumura
- Masashi Matsuyama (ORCID: https://orcid.org/0000-0002-8880-6951)
- Mizu Nonaka (ORCID: https://orcid.org/0000-0003-3815-784X)
- Naoki Arai
- Nobuyuki Hizawa
Institutions
- University of Tsukuba (JP)
- University of Tsukuba Hospital (JP)
- Tsukuba Medical Center Hospital (JP)
- Ibarakihigashi National Hospital (JP)
- Ibaraki University (JP)
Publication Details
- Journal
- American Journal of Respiratory and Critical Care Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1164/rccm.202503-0665oc
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35