Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to <scp>ATN</scp> Biomarkers and Cross‐Platform Validation
Compared with prior proteomic-based studies on the same dataset, our findings attained higher specificity and sensitivity for AD classification while utilizing a smaller panel of analytes. We also confirmed the reliability and consistency of this signature within a different population from a different platform. The plasma proteomic platforms explored were, however, not sufficient to determine MCI decliners versus non-decliners.
Authors
- Anna Matton (ORCID: https://orcid.org/0000-0002-7819-0495)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Oliver Robinson (ORCID: https://orcid.org/0000-0002-4735-0468)
- Merçé Boada (ORCID: https://orcid.org/0000-0003-2617-3009)
- Ming-guang Hu
- Raquel Puerta (ORCID: https://orcid.org/0000-0002-1191-5893)
- Christina M. Lill (ORCID: https://orcid.org/0000-0002-1903-6762)
- Lefkos Middleton (ORCID: https://orcid.org/0000-0002-2176-403X)
- Pilar Sánz
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of Münster (DE)
- Karolinska Institutet (SE)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institute for Neurodegenerative Disorders (US)
- Imperial College London (GB)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1002/acn3.70227
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Michael J. Fox Foundation for Parkinson's Research
- Alzheimer's Disease Neuroimaging Initiative
- Cure Alzheimer's Fund
- Agentschap Innoveren en Ondernemen
- EU Joint Programme – Neurodegenerative Disease Research
- European Federation of Pharmaceutical Industries and Associations
- UK Research and Innovation
- Ministerio de Ciencia, Innovación y Universidades
- Rare Diseases Clinical Research Network
- National Institute for Health and Care Research
- Imperial College London
- Deutsche Forschungsgemeinschaft
- China Scholarship Council
- Alzheimerfonden
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Grifols
- National Institutes of Health
- Instituto de Salud Carlos III
- European Regional Development Fund
- Center for Innovative Medicine
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences