Mitochondrial Oxidative Stress and Cardiac Dysfunction in <scp>TERT</scp> Deficient Progeria Mice

The findings demonstrate that third-generation TERT^-/- senescent mice exhibit significant cardiac impairments, including electrical remodelling, structural changes, and mitochondrial dysfunction, suggesting mitochondrial oxidative stress may be related to aging-related HF. These insights underscore the potential of targeting mitochondrial dysfunction for therapeutic strategies in aging-related HF. Collectively, these data demonstrate that telomerase deficiency drives cardiac structural and electrical remodelling through mitochondrial oxidative stress, underscoring mitochondrial quality control as a potential therapeutic target in aging-related HF.