Fucosylation limits <scp>ADCC</scp> in clinically used anti‐<scp>RhD</scp> monoclonal antibodies
Afucosylation of anti-D monoclonals mimics polyclonal anti-D and enhances their ADCC. Future efforts should focus on determining if these functional differences translate to clinical efficacy.
Authors
- Gestur Vidarsson (ORCID: https://orcid.org/0000-0001-5621-003X)
- Gabriela Koike (ORCID: https://orcid.org/0000-0002-5769-7908)
- E. J. T. Verweij (ORCID: https://orcid.org/0000-0002-9343-9957)
- Albert Bondt (ORCID: https://orcid.org/0000-0002-0985-7903)
- Douwe Schulte (ORCID: https://orcid.org/0000-0003-0594-0993)
- C. Ellen van der Schoot (ORCID: https://orcid.org/0000-0002-8065-3540)
- Albert J. R. Heck (ORCID: https://orcid.org/0000-0002-2405-4404)
- Peter C. Ligthart
- Rien Leuvenink
- Dirk Jan Mons
Institutions
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Sanquin (NL)
- Protestant Theological University (NL)
- Pharmo Institute (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Transfusion
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1111/trf.18449
- Citations
- 1
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Universiteit Utrecht