20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
These findings demonstrate that IR is a molecular target of 20(S)-PPD and reveal a mechanism by which 20(S)-PPD promotes longevity and stress resistance, suggesting the potential of 20(S)-PPD in slowing aging and the development of age-associated disorders.
Authors
- Limei Ren
- Xiaohao Xu (ORCID: https://orcid.org/0000-0002-6750-9704)
- Zhuo Song (ORCID: https://orcid.org/0000-0001-8711-7372)
- Fangbing Liu (ORCID: https://orcid.org/0000-0002-8527-4339)
- Shuai Zhang (ORCID: https://orcid.org/0009-0002-6420-8196)
- Tingting Lou
- Xiuci Yan
- Yu Wang (ORCID: https://orcid.org/0000-0002-5651-4751)
Institutions
- Changchun University of Chinese Medicine (CN)
- Jilin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fphar.2025.1657436
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- People's Government of Jilin Province