Inflammation-related biomarkers and berberine therapy in post-stroke depression: evidence from bioinformatics, machine learning, and experimental validation
This study identifies TLR2 and CYP1B1 as core inflammation-related genes in PSD. BBR demonstrates therapeutic efficacy as an active monomer compound against PSD, likely mediated through downregulating TLR2 and CYP1B1 expression, consequently diminishing the concentrations of pro-inflammatory mediators (IL-1β, IL-6, TNF-<i>α</i>) that mediate cerebroprotective actions.
Authors
- Jin Xu (ORCID: https://orcid.org/0000-0003-3072-1899)
- Y LI (ORCID: https://orcid.org/0000-0003-2410-0607)
- Wei Liu (ORCID: https://orcid.org/0000-0001-7974-849X)
- Ruheng Wei (ORCID: https://orcid.org/0000-0002-9475-9098)
- Zhilong Liu (ORCID: https://orcid.org/0000-0002-0401-5010)
Institutions
- Hebei North University (CN)
- Hebei Yiling Hospital (CN)
- Langfang Normal University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fnins.2025.1684297
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hebei North University