PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway
These results indicate that PGC-1α serves as a critical mediator in the FNDC5/BDNF/TrkB signaling pathway within newborn neurons. Enhancing PGC-1α expression, either pharmacologically or through alternative approaches, may therefore represent a promising therapeutic strategy for Alzheimer's disease.
Authors
- Guang Han (ORCID: https://orcid.org/0000-0001-7117-4241)
- Cheng‐Zhi Zou (ORCID: https://orcid.org/0000-0003-4124-6448)
- Hua Wang (ORCID: https://orcid.org/0000-0002-7288-5907)
- Jia Wang (ORCID: https://orcid.org/0000-0002-9544-9366)
- Yuxin Wang (ORCID: https://orcid.org/0000-0002-1629-4176)
- Yijie Wang (ORCID: https://orcid.org/0000-0001-6959-8619)
- Weijun Zhang (ORCID: https://orcid.org/0000-0002-9957-0438)
- Xin Qian (ORCID: https://orcid.org/0000-0002-8556-7473)
- Jiaqing Wang (ORCID: https://orcid.org/0000-0002-5827-1829)
- Feng-Guo Liu
- Wen Pan
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fnmol.2025.1688694
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00