Intravenously administered iron oxide nanoparticles with different coatings reversibly perturb immune cells in peripheral blood without inducing toxicity in mice
Iron oxide nanoparticle formulations exert a transient effect on the host immune system and some exhibit tumor accumulation, suggesting their potential for further development in cancer imaging and treatment.
Authors
- Robert Ivkov (ORCID: https://orcid.org/0000-0002-2930-5276)
- Chun-Ting Yang (ORCID: https://orcid.org/0000-0002-7667-244X)
- S. B. Healy (ORCID: https://orcid.org/0000-0003-4810-9593)
- Preethi Korangath (ORCID: https://orcid.org/0000-0002-6623-493X)
- Kathleen Gabrielson
- Cordula Grüttner (ORCID: https://orcid.org/0000-0002-8271-1281)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/ftox.2025.1673416
- Citations
- 2
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.19