Upregulated small GTPase immunity-associated proteins confer resistance to Neospora caninum in rat and bovine cells
Collectively, our findings imply that upregulation of GIMAP 4, 5, and 6 mediate robust refractoriness to <i>N. caninum</i> through induction of lysosomal fusion to the otherwise non-fusogenic PVM, resulting in vacuole acidification and destruction of intracellular parasites.
Authors
- William H. Witola (ORCID: https://orcid.org/0000-0002-2308-0539)
- Md. Mukthar Mia (ORCID: https://orcid.org/0000-0002-7495-0178)
- Amalina Ahmad Azam (ORCID: https://orcid.org/0000-0002-3911-7666)
- Julie Bedwani
Institutions
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1674380
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Illinois at Urbana-Champaign