Nanomaterial-assisted immunodiagnostic profiling and therapeutic targeting of hepatocellular carcinoma: from molecular biomarkers to clinical applications
By integrating transcriptomic and proteomic screening with epitope-level validation, we identified a novel panel of immunogenic biomarkers suitable for nanomaterial-enabled diagnostics in HCC. These findings support the translational potential of peptide-nano scaffold conjugates in developing minimally invasive, immune-responsive biosensing and therapeutic tools tailored for early-stage liver cancer management.
Authors
- Jianzeng Ye
- Xianpeng Li (ORCID: https://orcid.org/0009-0001-5162-0854)
- Kaipeng Huang (ORCID: https://orcid.org/0000-0003-2269-0383)
- Liu L (ORCID: https://orcid.org/0000-0001-9234-457X)
- Jiping Luo
- Ziyu Cheng
Institutions
- University of Toronto (CA)
- Southern University of Science and Technology (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1668630
- Citations
- 2
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Zhejiang Province