Comparative analysis of Acinetobacter baumannii bloodstream isolates from children and adults in southern China
These findings demonstrate age-related differences in the resistance and virulence profiles of <i>A. baumannii</i> bloodstream isolates. Pediatric isolates exhibited higher carbapenem resistance and virulence gene prevalence, whereas adult isolates showed greater clonal diversity. This comparative analysis enhances understanding of <i>A. baumannii</i> pathogenesis across age groups and provides insights for guiding empirical therapy and strengthening infection control strategies.
Authors
- Hui Xu (ORCID: https://orcid.org/0000-0003-0499-2409)
- Cheng Li (ORCID: https://orcid.org/0000-0001-7912-0643)
- Xingran Du (ORCID: https://orcid.org/0000-0003-3964-2070)
- Rui Zhao (ORCID: https://orcid.org/0000-0003-3769-6550)
- Tiantian Zhang (ORCID: https://orcid.org/0000-0002-5084-6333)
- Fen Xue (ORCID: https://orcid.org/0009-0002-3361-1206)
- Fan Fei (ORCID: https://orcid.org/0009-0001-1622-9462)
- Sen Liang (ORCID: https://orcid.org/0009-0003-1082-0061)
- Nan Gao (ORCID: https://orcid.org/0000-0003-2044-0292)
- Yanfeng Zhao (ORCID: https://orcid.org/0000-0002-4605-9783)
- Xing Wang (ORCID: https://orcid.org/0000-0002-0036-191X)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Jiangning Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1684049
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing Medical University