Network pharmacology and molecular docking analyses of the Wuwei Mingmu formula indicate that IL-10 and IL-6 are critical targets against experimental autoimmune uveitis in rats
WMF can be used to treat EAU as it can modulate immune responses and vascular functions. IL-10 and IL-6 are the main therapeutic targets of WMF, and the herbal composition of WMF can be further optimized to increase its therapeutic efficacy.
Authors
- Yajian Duan
- Junkun Zhang (ORCID: https://orcid.org/0000-0003-2515-5087)
- Jie Li (ORCID: https://orcid.org/0000-0002-3825-5143)
- Liang Xing
- Liang Li (ORCID: https://orcid.org/0000-0002-1577-408X)
- Yuan Fang (ORCID: https://orcid.org/0000-0002-2700-690X)
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fphar.2025.1614561
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00