Incidence of adrenal crisis in children and young people receiving high dose glucocorticoids for nephrotic syndrome or juvenile idiopathic arthritis: a retrospective observational study
This study suggests that supraphysiological GC administered for several weeks can potentially be weaned and stopped safely without formal biochemical assessment in patients with NS and JIA. Specialist teams provide families with rapid access to advice which supports safe practice. An alternate day weaning regimen following a modest period of daily supraphysiological GC may have reduced the likelihood of AS at critical times.
Authors
- Yincent Tse (ORCID: https://orcid.org/0000-0003-3175-1475)
- Claire Louise Wood (ORCID: https://orcid.org/0000-0002-6084-5174)
- Joanne Finnie (ORCID: https://orcid.org/0009-0003-2726-6896)
- Tim Cheetham (ORCID: https://orcid.org/0000-0003-3120-2513)
- Sunil Sampath (ORCID: https://orcid.org/0000-0001-5134-3036)
- Hisham Alawad
Institutions
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Newcastle upon Tyne Hospital (GB)
- Great North Children's Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Archives of Disease in Childhood
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1136/archdischild-2025-328917
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00