Identification of an anti-inflammatory action of exosome release in P2Y4 loss-mediated cardioprotection
These data support the role of the release of anti-inflammatory exosomes, and more particularly the exosomal form of PD-L1 and adiponectin, in P2Y<sub>4</sub> loss-mediated cardioprotection. The study of regulators of cardioprotective exosomes could lead to the development of novel anti-inflammatory therapies to improve myocardial infarction outcome.
Authors
- Lucas De Roeck
- Esteban Diaz Villamil (ORCID: https://orcid.org/0000-0001-8457-9678)
- Didier Communi (ORCID: https://orcid.org/0000-0003-1050-1493)
- Michael Horckmans
- Louise Conrard
- Erika Hendrickx (ORCID: https://orcid.org/0009-0008-7682-5910)
- Paul Rouvier
Institutions
- Université Libre de Bruxelles (BE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fphar.2025.1664015
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fédération Wallonie-Bruxelles
- Vrije Universiteit Brussel
- Innoviris
- Koning Boudewijnstichting