KIF1Bβ suppresses hepatocellular carcinoma by transporting and secreting FBLN5 to attenuate the integrin pathway
Our findings shed light on the genetic and molecular mechanisms of the HCC-associated susceptibility locus at 1p36.22 and provide potential new strategies for the treatment of HCC.
Authors
- Junjie Wu (ORCID: https://orcid.org/0000-0002-4000-7026)
- Rui Guo (ORCID: https://orcid.org/0000-0001-7417-7018)
- Rong Liang (ORCID: https://orcid.org/0000-0003-0343-3277)
- Guangming Zhou (ORCID: https://orcid.org/0000-0001-5695-2308)
- Xiaoyu Hu (ORCID: https://orcid.org/0000-0002-8832-9446)
- Yifei Qiu
- K. D. Hao (ORCID: https://orcid.org/0009-0008-2559-0883)
- Tao Zeng (ORCID: https://orcid.org/0000-0001-8896-0361)
- Chenning Yang
- Pengbo Cao (ORCID: https://orcid.org/0000-0002-7820-114X)
- Ruofan Li (ORCID: https://orcid.org/0000-0001-7746-9569)
- Yuanfeng Li (ORCID: https://orcid.org/0000-0001-8227-7019)
- Jiazhou Ye (ORCID: https://orcid.org/0000-0001-9124-7284)
- Fuchu He (ORCID: https://orcid.org/0000-0002-8571-2351)
- Yuting Wang (ORCID: https://orcid.org/0000-0003-0555-7433)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4082-5026)
- Han Yan (ORCID: https://orcid.org/0000-0003-2789-0798)
- Qiming Wang (ORCID: https://orcid.org/0000-0002-9386-5091)
- Jiao Wang (ORCID: https://orcid.org/0000-0001-7399-5705)
- Yahui Wang (ORCID: https://orcid.org/0000-0001-6645-8485)
- Chang Gao (ORCID: https://orcid.org/0000-0002-1207-7457)
- Furong Cheng
- Jinwen Zhang (ORCID: https://orcid.org/0000-0001-8760-1703)
- Song Liao
- Peipei Shi (ORCID: https://orcid.org/0000-0003-3399-0154)
- Hongbo Yan
Institutions
- Guangxi Medical University (CN)
- Second Military Medical University (CN)
- Anhui Medical University (CN)
- Nanjing Health and Health Commission (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Changhai Hospital (CN)
- Beijing Proteome Research Center (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- Hebei University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1136/gutjnl-2025-336230
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00