The effect of folates on the oxidation reaction of methyl linoleate in micellar solutions

The antiradical/antioxidant properties of folic acid (FA) and its conformational derivatives – 7,8-dihydrofolate (DHF), 5,6,7,8-tetrahydrofolate (THF) and 5-formyl-5,6,7,8-tetrahydrofolate (5-FTHF) – were studied at the physiological temperature and pH in the micellar aqueous system of the model reaction of methyl linoleate peroxidation with molecular oxygen. It was established that folates exhibit antioxidant properties, thereby inhibiting the peroxidation of methyl linoleate.Quantitative kinetic studies of selected folates revealed the comparative growing order of the antiradical/antioxidant reactivities: FA < 5-FTHF < THF ≅ DHF.Investigation of the antioxidant properties of folates is urgent for understanding their role in the prevention of pathologies in the body. They may have potential in treating numerous pathological conditions in which oxidative stress is a clinically important component.