KDM5A, a H3K4me3 demethylase, regulates skin wound healing by promoting M2 macrophage polarization via suppression of Socs1

Our findings demonstrate that KDM5A modulates wound healing by epigenetically regulating Socs1 expression. Downregulation of KDM5A in wound macrophages relieves the repression of Socs1, thereby driving M2 polarization and creating a pro-regenerative microenvironment that facilitates tissue repair. This study elucidates the KDM5A-Socs1 molecular axis as a key epigenetic regulator in wound healing and establishes a conceptual framework for developing novel therapeutic strategies.