SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway

Our study revealed a novel regulatory role of SOCS2 in EC injury following TBI and elucidated its underlying mechanism. This discovery of the previously unknown role of the SOCS2-PARP1-JAK2/STAT3 regulatory axis in the TBI-related damage to ECs will provide new ideas for the development of neuroprotective strategies targeting SOCS2.

Authors

Shu Deng (ORCID: https://orcid.org/0000-0001-8353-6705)
Wenquan Che (ORCID: https://orcid.org/0000-0002-9388-6570)
Hao Zhang (ORCID: https://orcid.org/0000-0002-1639-4089)
Yang Gui (ORCID: https://orcid.org/0000-0002-2199-6340)
Lei Yang (ORCID: https://orcid.org/0009-0003-5034-3511)

Institutions

Kunming Children's Hospital (CN)
Dali University (CN)

Publication Details

Journal: Metabolic Brain Disease
Published: 2025-10-14
DOI: https://doi.org/10.1007/s11011-025-01724-5
Primary Topic: Cytokine Signaling Pathways and Interactions
Type: article
Field-Weighted Citation Impact: 0.00

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article

SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway

Shu Deng, Wenquan Che, Hao Zhang, Yang Gui et al.

Oct 14, 2025

Metabolic Brain Disease

Cytokine Signaling Pathways and Interactions

article

SOCS2 alleviates traumatic brain injury-induced mitochondrial damage and parthanatos in endothelial cells by inhibiting the JAK2/STAT3 signaling pathway

Shu Deng, Wenquan Che, Hao Zhang, Yang Gui, Lei Yang

October 14, 2025article en

Abstract

Our study revealed a novel regulatory role of SOCS2 in EC injury following TBI and elucidated its underlying mechanism. This discovery of the previously unknown role of the SOCS2-PARP1-JAK2/STAT3 regulatory axis in the TBI-related damage to ECs will provide new ideas for the development of neuroprotective strategies targeting SOCS2.

Metabolic Brain DiseaseVol. 40(7)

Kunming Children's Hospital (CN), Dali University (CN)

Openalex Percentile: Top 61%

Cytokine Signaling Pathways and Interactions

DOI Open Access PDF OpenAlex

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