(Es)ketamine as a treatment for depressive episodes with psychotic features: systematic review
The available evidence suggests that (es)ketamine shows antidepressant effects in patients with depressive episodes with psychotic features and has a reasonable safety profile. However, the heterogeneity of the studies included in this review and the high risk of bias warrant caution in interpreting the findings and underscore the need for further trials to confirm these preliminary results.
Authors
- Mário F. Juruena (ORCID: https://orcid.org/0000-0001-8558-3396)
- Henrique Castro Santos (ORCID: https://orcid.org/0000-0001-9926-3887)
- Allan H. Young (ORCID: https://orcid.org/0000-0003-2291-6952)
- Manuel Gonçalves‐Pinho (ORCID: https://orcid.org/0000-0001-6098-429X)
- Tiago Luís Gonçalves Neves Machado (ORCID: https://orcid.org/0000-0001-8930-4382)
- Alexandra Rodrigues (ORCID: https://orcid.org/0000-0001-6241-9446)
Institutions
- University of Lisbon (PT)
- Universidade do Porto (PT)
- King's College London (GB)
- Bethlem Royal Hospital (GB)
- Centro Hospitalar do Tâmega e Sousa (PT)
- Sydney Local Health District (AU)
- Hospital Dr. Nélio Mendonça (PT)
- Imperial College London (GB)
Publication Details
- Journal
- BJPsych Open
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1192/bjo.2025.10830
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00