Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches
We show that the EpiAnceR+ approach improves the adjustment for genetic ancestry in DNA methylation studies. EpiAnceR+ can be integrated into existing R pipelines for commercial methylation arrays, such as 450 K, EPIC v1, and EPIC v2. The code is available on GitHub ( https://github.com/KiraHoeffler/EpiAnceR ).
Authors
- Bjarne Hansen (ORCID: https://orcid.org/0000-0001-5659-1119)
- Kira D. Höffler (ORCID: https://orcid.org/0000-0002-0837-1469)
- Stéphanie Le Hellard (ORCID: https://orcid.org/0000-0002-8085-051X)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Şeyma Katrinli (ORCID: https://orcid.org/0000-0003-1575-8642)
- James J. Crowley (ORCID: https://orcid.org/0000-0001-9051-1557)
- Srdjan Djurovic (ORCID: https://orcid.org/0000-0002-8140-8061)
- Jan Haavik (ORCID: https://orcid.org/0000-0001-7865-2808)
- Gerd Kvale (ORCID: https://orcid.org/0000-0001-5449-2344)
- Kristen Hagen (ORCID: https://orcid.org/0000-0002-4286-1277)
- Matthew Halvorsen (ORCID: https://orcid.org/0000-0002-6707-2418)
- Gabriel R. Fries (ORCID: https://orcid.org/0000-0002-5468-2612)
- Anne-Kristin Stavrum (ORCID: https://orcid.org/0000-0002-5482-1141)
- Kevin S. O’Connell (ORCID: https://orcid.org/0000-0002-6865-8795)
- Jair C. Soares (ORCID: https://orcid.org/0000-0002-5466-5628)
- Alicia K. Smith (ORCID: https://orcid.org/0000-0002-8537-5156)
- Ole A. Andreassen
- Kerry J. Ressler
Institutions
- University of North Carolina at Chapel Hill (US)
- Oslo University Hospital (NO)
- Harvard University (US)
- Emory University (US)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Haukeland University Hospital (NO)
- McLean Hospital (US)
- Molde Hospital (NO)
- Senter for Krisepsykologi (NO)
- University of Bergen (NO)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s13072-025-00627-0
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81